【摘要】 目的:研究荭草苷对缺氧模型小鼠的抗缺氧作用。方法:通过常压耐缺氧、亚硝酸钠中毒、氰化钾中毒、利多卡因中毒、夹闭气管及断头等建立小鼠缺氧模型,于造模前20min给予相应药物,观察药物的抗缺氧作用。结果:与生理盐水空白对照组比较,荭草苷可明显延长模型小鼠在常压缺氧、亚硝酸钠中毒、氰化钾中毒、利多卡因中毒时的存活时间,延长夹闭气管后的心电图消失时间及断头后的喘气时间。结论:荭草苷对缺氧模型小鼠具有抗缺氧作用。更多还原

【Abstract】 OBJECTIVE:To evaluate the antihypoxic effect of orientoside on hypoxia model rats.METHODS:The hy-poxia rats model was established through normobaric hypoxia,poisoning with sodium nitrite,potassium cyanide and lidocaine,trachea occlusion,decapitation,etc.20minutes prior to the modeling,the rats were administered with the corresponding drugs with the anti-hypoxic effects observed.RESULTS:As compared with placebo group,the survival time of rats under nor-mobaric hypoxia,poisoned by sodium nitrite,potassium cyanide and lidocaine,and the electrocardiograph extinction time after trachea occlusion and the gasping time of mice after decapitation were all significantly prolonged by orientoside.CONCLU-SION:Orientoside has antihypoxic effect on hypoxia model rats.更多还原