【摘要】 目的探讨品行障碍(CD)与5-羟色胺转运体基因遗传多态性的关系。方法对88例CD患者(病例组)和60例正常对照组提取基因组DNA,采用RFLP技术分析相应的基因型,并比较2组不同基因型的行为特点有无差异。结果CD患者的5-羟色胺转运体基因多态性基因型L/L频率(43.2%)较正常对照组(26.7%)明显为多,且差异在儿童起病型中明显(P<0.05);伴有ADHD的CD患儿基因型L/L的频率(44.0%)较正常对照组(24.1%)显著为高,两者存在关联,基因型为S/S的CD患儿血浆5-HT水平[(0.85±0.32)μm l/L]显著低于S/L和L/L基因型患者[(1.14±0.52)μm l/L](P<0.05)。结论5-羟色胺转运体基因多态性基因型L/L频率较正常对照组显著为高,等位基因L的个体5-HT活性较低,提示其与CD有一定关联,可能是CD的易感基因。更多还原

【Abstract】 Objective To investigate the relationship between serotonin transporter promoter polymorphisms(5-HTTLPR) and conduct disorder(CD) in a Chinese Han population.MethodsComparing 88 patients diagnosed as conduct disorder and 60 healthy control subjects.Genotype and allele frequencies of 5-HTTLPR was analyzed with polymerase chain reaction-restrain fragment length polymorphism.ResultsThe frequencies of L/L genotype of 5-HTTLPR in CD patients especially those with childhood onset was significantly higher than those in normal controls(P<0.05).CD patients with the S/L or L/L genotype showed a significant enhancement of plasma 5-HT level(P<0.05).ConclusionSubjects with allele S of 5-HTTLPR showed a decreased serotonergic neurotransmission which suggest it might be responsible for a increase in susceptibility for CD.更多还原