【摘要】 目的探索汉族人群中多巴胺转运体可变数目串联重复区基因多态性与强迫症的发病关系。方法对强迫症和正常对照组分别采用聚合酶链反应扩增片断长度多态技术测定基因型。结果测到4种等位基因8,9,10,11。强迫症患者与正常对照组DATVNTR的等位基因及基因型频率差异无显著性(2=4.012,P=0.581;2=4.311,P=0.334)。结论在汉族人群中,DATVNTR基因多态性基因型和等位基因与强迫症无明显关联。更多还原

【Abstract】 Objective To explore the association between polymorphism of dopamine transporter variable number tandem repeat(DATVNTR) and obsessive-compulsive disorder(OCD) in the Han nationalitve.MethodsOCD patients and normal controls were included in this study.The subjects were genotyped directly for the 5-HTTLPR with polymerase chain reaction amplification fragment length polymorphism techniques.(Results)There were no significant differences between OCD patients and normal controls in the frequencies of genotype and allele for DATVNTR(~2=4.012,P=0.581;~2=4.311,P=0.334).ConclusionThere were no significant association in DATVNTR gene polymorphism between OCD patients and normal controls.更多还原