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咖啡因改善糖尿病大鼠膀胱功能的观察
Effects of caffeine on bladder dysfunction in diabetic rats
【摘要】 咖啡因治疗7周后,糖尿病鼠膀胱湿重与阈容量(V)显著降低,相对排尿量(V%)与环磷腺苷含量明显升高,逼尿肌收缩性有所改善。咖啡因可能具有防治糖尿病膀胱病的作用。
【Abstract】 Compared with DM group, the bladder wet weight and volume threshold for micturation were significantly reduced in caffeine-treated DM group,while V% and cAMP content were significantly increased. Caffeine can significantly ameliorate the impaired bladder detrusor contractility of diabetic rats. These results suggest that caffeine may have a beneficial effect on bladder dysfunction in the diabetic rats.
【基金】 江苏省应用基础研究科技计划资助项目(BJ2000057);江苏省“135”重点学科专项资助项目;南京市医学科技发展基金资助项目(YKK0443)
- 【文献出处】 中国糖尿病杂志 ,Chinese Journal of Diabetes , 编辑部邮箱 ,2006年02期
- 【分类号】R587.2
- 【被引频次】13
- 【下载频次】205