【摘要】 目的观察添加谷氨酰胺双肽的肠外营养对严重烧伤患者T淋巴细胞亚群的影响。方法28例烧伤总面积60.7%±10.0%,深Ⅱ度、Ⅲ度烧伤面积32.1%±4.6%的患者随机分为对照组和实验组,每组14例,两组患者均接受等氮等热卡的肠外营养一周,实验组同时给予谷氨酰胺双肽0.5g.kg-1.d-1。检测入院时(伤后第1天)、用药前(伤后第3天)、用药后(伤后第11天)外周血CD3、CD4、CD8、CD4/CD8。结果伤后第11天,实验组CD4(37.24%±6.34%)和CD4/CD8(1.72%±0.23%)水平均显著高于对照组(分别为25.34%±7.17%和1.02%±0.21%,P<0.05)。结论含谷氨酰胺双肽的肠外营养影响T淋巴细胞亚群的变化,可改善严重烧伤患者的免疫功能。更多还原

【Abstract】 Objective To evaluate the effects of parenteral nutrition supplemented with glutamine dipeptide on T-lymphocyte subgroups in severely burned patients. Methods Twenty-eight severely burned patients were randomly divided into control group (n=14) and glutamine dipeptide group(GD group, n=14). All patients received same nitrogen and calorie for one week. Patients in the GD group were additionally supplemented with glutamine dipeptide (0.5 g·kg -1 ·d -1 ). Blood samples were obtained for measurement of CD_ 3 ,CD_ 4 ,CD_ 8 ,and CD_ 4 /CD_ 8 on day 1,3,and 11 after burn. Results On the day 11 after burn,the CD_ 4 (37.24%±6.34%) and CD_ 4 /CD_ 8 levels(1.72%±0.23%) in GD group were significantly higher than CD_ 4 (25.34%±7.17%) and CD_ 4 /CD_ 8 (1.02%±0.21%) in control group. Conclusion Parenteral nutrition supplemented with glutamine dipeptide may affect T-lymphocyte subgroups and improve the immune function of severely burned patients.更多还原