【摘要】 目的探讨手术治疗对高血压脑出血患者血清S-100蛋白浓度的影响及其临床意义。方法选择出血量30￣50ml的脑出血患者67例,分为手术组35例和保守组32例。用ELISA法动态测定血清中S-100蛋白的浓度。同时与30例健康者(正常组)血清S-100蛋白浓度进行比较。结果①保守组患者血清S-100蛋白浓度在发病21d内高于正常组(P<0.01)。②手术组患者血清S-100蛋白浓度在发病7d内高于正常组(P<0.01),15d和21d时与正常组比较无显著性差异(P>0.05)。③手术组患者血清S-100蛋白浓度在发病后15d和21d时明显低于保守组(P<0.01)。结论手术清除血肿可以减轻脑出血患者的脑损伤。更多还原

【Abstract】 Objective To explore the effect of surgery on the serum S-100 protein concentration in patients with hypertensive intracerebral hemorrhage and Its clinical meaning. Method Sixty-seven patients with hypertensive intracerebral hemorrhage, in whom hematoma volumes varied between 30ml to 50ml, were divided into operative treatment group (35 cases) and conservative treatment group (32 cases). The serum concentration of S-100 protein was detected by ELISA method in all the patients and 30 healthy subjects (normal group). Results ①The serum concentration of S-100 protein in the conservative group was significantly higher than that in the normal group within 21 days after the hemorrhage (P<0.01). ②The serum concentration of S-100 protein in the operative group was significantly higher than that in the normal group within 7 days after the hemorrhage (P<0.01), but not 15 days and 21 days after the hemorrhage (P>0.05). ③ The serum concentration of S-100 protein was significantly lower in the operative group than that in the conservative group 15 day and 21 days after the hemorrhage (P<0.01). Conclusions Evacuation of hematoma can reduce damage to the brain after the hypertensive intracerebral hemorrhage.更多还原