【摘要】 目的探讨高血压患者血糖水平与冠状动脉狭窄的关系。方法本研究回顾性分析540例因胸痛住院接受冠状动脉造影且规则接受药物治疗下高血压患者的血清空腹血糖、服糖后2h血糖水平与冠状动脉狭窄的相关性。根据血糖水平(血糖耐量试验2h糖值)将研究对象分为3组,第1组,2h血糖<7·8mmol/L;第2组,2h血糖为7·8~11·0mmol/L;第3组,2h血糖≥11·1mmol/L。观察2h血糖水平与冠状动脉硬化程度之间的关系。分析在随访的24月死亡36例的情况。结果随着血糖水平增高,冠状动脉狭窄级数、狭窄≥75%血管支数和狭窄≥75%的例数均明显增加(P<0·01)。血糖升高的患者,24月内的主要心血管事件以及死亡均升高,其中2h血糖≥11·1mmol/L组死亡率高于血糖正常组(第3组11·0%比第1组2·9%,P<0·05)。左心室射血分数(LVEF)在血糖升高的两组明显降低[(第2组54·1±10·2)和(第3组53·8±9·9)]比(第1组58·1±9·6,P<0·05)。结论在高血压患者中随着血糖水平升高,冠脉狭窄程度和近期死亡危险增加。更多还原

【Abstract】 Objective To investigate the relationship between blood glucose levels and severity of coronary stenosis in hypertensive patients. Methods Blood pressure, fasting plasma glucose, 2 h plasma glucose, clinical features and coronary angiographic findings were analyzed retrospectively in 540 patients with essential hypertension. Acoording 2 h plasma glucose, patients were stratified into three group: group 1: 2h plasma glucose <7.8 mmol/L; group 2: 2 h plasma glucose 7.8-11.0 mmol/L;group 3: 2 h plasma glucose ≥11.1 mmol/L. The relation of coronary stenosis and blood glucose level was analyzed. Results The severity of the coronary stenosis was positively related to 2 h plasma glucose levels (P<0.01). Mortality rate in 24 months was significantly higher in the group 3 (11.1%) than that in the group 1 (2.9%, P<0.05). LVEF in the group 3 and group 2 were decreased(group 3: 53.8±9.9 and group 2: 54.1±10.2 vs group 1: 58.1±9.6,P<0.05). Conclusion The severity of coronary artery stenosis and mortality rate were increased in hypertensive patients with the elevated glucose level.更多还原