【摘要】 目的探讨纳米锌材料对小鼠血清生化指标的影响。方法小鼠以5 g/(kg.bw)剂量的纳米或微米粒径锌粉一次经口灌胃,14 d后处死取血清,观察血清常规生化指标的变化。结果纳米锌粉组小鼠血清除乳酸脱氢酶(LDH)和α-羟丁酸脱氢酶(HBDH)与对照组比较有明显升高外(P<0.05),其余血清生化指标与对照组相比较差异无统计学意义(P>0.05);而微米锌粉组小鼠血清LDH、HBDH、丙氨酸氨基移换酶(ALT)、碱性磷酸酶(ALP)、假性胆碱脂酶(ChE)等多个生化指标均比对照组有明显升高(P<0.05);纳米锌粉组小鼠血清LDH、HBDH、ChE等生化指标水平明显低于微米锌粉组(P>0.05)。结论纳米级锌粉对小鼠血清生化指标的影响与微米锌粉有所不同。更多还原

【Abstract】 Objective To explore the effect of Nano-zinc powder on mice serum biochemical indexes.Methods The mice were treated by one single oral dose of nano-zinc or micron-zinc powder at 5?g/(kg·bw).After14 days,the mice were sacrificed and the serum were collected for biochemical analysis.Results In Nano-zinc group,only the serum LDH,HBDH were obviously higher than that in control group(P>0.05),but in micron-zinc powder group,the serum LDH,HBDH,ALT,ALP,CHE,LAP,TP,ALB,AST,UA,BUN,Ca,P,TG were higher significantly than that in control group(P>0.05).The serum LDH,HBDH,ChE,LAP,TP,ALB,Ca of Nano-zinc group were lower than those in micron-zinc powder group significantly(P> 0.05).Conclusion In general the Nano-zinc has difference effect on mice biochemical indexes as compared with the micron zinc powder.更多还原