【摘要】 目的探讨T淋巴细胞表面C-C趋化因子受体5(CCR5)在丙型肝炎病毒(HCV)感染、人类免疫缺陷病毒(HIV)感染和HCV/HIV合并感染过程中的表达及意义。方法采用流式细胞术检测HCV感染组(n=21例),HIV感染组(n=14例),HCV/HIV感染组(n=28例)及正常对照组(n=30例)人外周血CD4+和CD8+T淋巴细胞表面CCR5的表达。结果与正常对照组相比,外周血CD4+和CD8+T淋巴细胞表面CCR5,HIV感染组高表达(P<0.01),HCV感染组和HCV/HIV合并感染组中低表达(P<0.01)。结论淋巴细胞表面CCR5的表达,HIV感染时升高、HCV感染时降低,HCV/HIV合并感染时HCV感染的作用更强。更多还原

【Abstract】 Objective To investigate expression and significance of CC-chemokine receptor 5(CCR5) in HCV mono-infection,HIV mono-infection and HCV/HIV co-infection.Methods The surface expression of CCR5 on CD4~+T cells and CD8~+T cells from PBMC isolated from HCV infection(n=21),HIV infection(n=14),HCV/HIV co-infection(n=28) and normal control(n=30) by flow cytometry.Results The expression of CCR5 on CD4~+ and CD8~+ T lymphocytes increased significantly in HIV mono-infection(P<0.01),but decreased significantly both in HCV mono-infection and HCV/HIV co-infection(P<0.01).Conclusion The surface expression of CCR5 on lymphocytes increased with HIV infection,decreased with HCV infection.In HCV/HIV co-infection,HCV maybe effect on the expression of CCR5 on lymphocytes.更多还原