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富硒蛋白对小鼠免疫功能影响

Effect of selenium-enriched protein on immune function of mice

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【作者】 杜莹王晓燕解清欧阳荔魏雪涛王京宇

【Author】 DU Ying,WANG Xiaoyan,XIE Qing,et al.School of Public Health,Peking University(Beijing 100083,China)

【机构】 北京大学公共卫生学院北京大学公共卫生学院 北京100083沈阳市和平区疾病预防控制中心北京100083

【摘要】 目的观察富硒蛋白对正常小鼠免疫功能的影响作用。方法选用48只健康的ICR小鼠,随机分成4组,在饲料中分别加入贫硒蛋白、贫硒蛋白与亚硒酸钠混合物、富硒牛奶、富硒蛋白,进行30 d的喂饲后测定小鼠淋巴器官指数、迟发型变态反应、溶血空斑形成数。结果富硒蛋白能够促进小鼠溶血空斑的形成,刺激迟发型变态反应,作用优于相同硒含量的富硒牛奶或者贫硒蛋白与无机硒的混合饲料(P<0.05)。结论该富硒蛋白产品有提高小鼠体液免疫、细胞免疫功能的作用。

【Abstract】 Objective To study the influence of selenium-enriched proteins,which were made from selenium-enriched milk,on the immune function of the health mice.Methods Forty-eight healthy mice were chosen and randomly divided into 4 groups:normal milk group,normal milk+inorganic selenium(Na2SeO3) group,selenium-enriched milk group,selenium-enriched protein group.30days later,the index of lymphoid organ of mice,delayed-type hypersensitivity(DTH),the number of plague forming cell were determined,respectively.Results The selenium-enriched protein could increase the number of plague forming cell(PFC),and stimulated DTH.Its influence on the immune of the mice was stronger than those form normal milk+inorganic selenium group and selenium-enriched milk group under the same dosage.Conclusion The selenium-enriched protein can improve cellular immunity and humoral immunity of mice.

  • 【文献出处】 中国公共卫生 ,Chinese Journal of Public Health , 编辑部邮箱 ,2006年01期
  • 【分类号】R151
  • 【被引频次】34
  • 【下载频次】480
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