【摘要】 目的探讨不稳定性心绞痛患者外周血CD4+CD25+调节性T细胞(Treg)水平及意义。方法采用流式细胞分析法,检测13例不稳定性心绞痛患者、8例稳定性心绞痛患者和10例胸痛综合征患者外周血CD4+CD25+Treg占CD4+T细胞比例。结果不稳定性心绞痛患者外周血 Treg/CD4+T细胞比例(10．1±3．4％)显著低于稳定性心绞痛组(14．2±2．9％)和胸痛综合征组 (16．5±4．9％)。结论不稳定性心绞痛患者外周血Treg比例减少。Treg比例降低可能打破了外周免疫耐受,参与了动脉粥样硬化的发生发展。更多还原

【Abstract】 Objective The aim of study was to explore the significance of the change of CD4 + CD25 + regulatory T cells (Treg) in patients with unstable angina. Methods The frequencies of CD4 + CD25 + Treg were detected in 13 patients with unstable angina, 8 patients with stable angina and 10 patients with chest pain syndrome by flow cytometry. Results The frequencies of CD4 + CD25 + Treg were found to be significantly lower in patients with unstable angina ( 10. 1±3.4% ) than those of stable angina ( 14. 2±2.9% ) and chest pain syndrome (16. 5±4.9% ) . Conclusion The frequencies of Treg decrease in patients with unstable angina. The decrease of Treg may lead to the breakdown of peripheral autoimmune tolerance and participate in the progression of atherosclerosis.更多还原