【摘要】 目的超声心动图左室中层机制评价西尼地平对高血压患者左室收缩功能的影响。方法正常对照30例;35例轻中度高血压患者,经2周安慰剂期后,给予西尼地平治疗8周,于安慰剂期末和8周末行超声心动图检查测算传统收缩功能指标射血分数(EF)、短轴缩短率(eFS),较符合生理特点的左室中层缩短率(mFS)。结果(1)高血压患者eFS和EF治疗前后均比对照组高(P<0.05,P<0.01);而高血压组mFS治疗前比对照组低(P<0.05),治疗8周后与对照组比差别无统计学意义(P=0.963);(2)治疗前后eFS、EF无明显变化(P均>0.05),而治疗8周后mFS比治疗前增高(P<0.01)。结论超声心动图mFS比EF、eFS能更敏感、准确地检测高血压患者左室收缩功能的降低,西尼地平能够改善患者mFS评价的收缩功能。更多还原

【Abstract】 Objective To assess the effects of cilnidipine on left ventricular systolic function via echocardiographic conventional systolic function measurements and midwall fractional shortening (mFS) in hypertensive patients.Methods Thirty normal subjects as the control and 35 patients with mild to moderate essential hypertension after a 2-week placebo run-in period,were treated with cilnidipine for 8 weeks.At the end of placebo period and 8 weeks the patients were examined with echocardiography for measuring and calculating ejecton fraction(EF),endocardial fraction shortening(eFS) and mFS.Results (1)Compared with the control group,in the hypertensive group eFS and EF were increased with P<0.05,P<0.01 respectively;mFS of hypertensive patients were lower at the end of placebo period(P<0.05),but not different at the end of 8 weeks (P=0.963).(2)At the end of 8 weeks,EF and eFS did not change(P>0.05),however mFS were increased significantly(P<0.01).Conclusions Echocardiographic mFS is more reliable and sensitive than EF and eFS in the assessment of left ventricular systolic function;cilnidipine can improve left ventricular systolic function expressed in mFS.更多还原