【摘要】 目的测定原发性高血压患者血浆组织型纤溶酶原激活剂(t-PA)及其抑制物(PA I-1)水平及左室超声背向散射积分(IBS)参数的变化,评价纤溶活性在心肌胶原网络重构发生、发展中的作用。方法按WHO/ISH(1999年)高血压诊断标准选择原发性高血压(EH)患者106例,正常对照组30例。根据左室质量指数将高血压患者分为左室肥厚(EH-LVH)组50例及非肥厚(EH-NLVH)组56例。用ELISA法测血浆t-PA与PAI-1含量,HP Sonos5500型多普勒超声仪测定室间隔IBS参数(AII、PPI、CAI),并对上述指标的相关性进行分析。结果与对照组相比,EH-LVH组和EH-NLVH组PAI-1、AII、CAI升高,t-PA、PPI降低,与EH-NLVH组相比,EH-LVH组AII、CAI升高,t-PA降低。相关分析显示:PAI-1与AII、CAI、LVMI呈正相关关系,与PPI呈负相关关系;t-PA与AII、CAI、LVM呈负相关关系,与PPI呈正相关关系。结论高血压患者存在纤溶功能异常和心肌及胶原网络重构,血浆PAI-1升高和t-PA降低在左室心肌及胶原网络重构的形成中发挥了一定的作用。更多还原

【Abstract】 Objective To evaluate relations between the serum of plasmatic tissue-type plasminogen activator(t-PA),plasminogen activator inhibitor-1(PAI-1) concentration and echocardiographic integrated backscatter(IBS) in patients with essential hypertension(EH).Methods The study was performed in 106 EH(50 patients with left ventricular hypertrophy as EH-LVH group and 56 patients without left ventricular hypertrophy as EH-NLVH group) and 30 normotensive control subjects.The plasmatic concentration of t-PA and PAI-1 was measured with ELISA.IBS parameters such as average image intensity(AII) and peak to peak intensity(PPI) of interventricular septum were measured echocardiographically.Results AII and corrected acoustic intensity(CAI) in the EH-LVH and EH-NLVH groups were higher than those in the control group.PPIs were lower.PAI-1 in EH-LVH and EH-NLVH groups was increased than that in the control group.The t-PA was decreased in EH-LVH and EH-NLVH groups and was lower in EH-LVH group than that in EH-NLVH group.AII was correlated with PAI-1 and t-PA(r=0.57,-0.51 respectively).The PAI-1 and t-PA were correlated with LVMI(r=0.67,-0.58 respectively).Conclusions The findings showed that PAI-1,t-PA had taken part in myocardial collagen network remodeling.更多还原