【摘要】 目的研究丙氨瑞林对子宫内膜增生的治疗作用,以及对增生内膜雌激素受体(ER)、孕激素受体(PR)和促性腺激素释放激素受体(GnRHR)是否有调节作用。方法对诊刮确诊为子宫内膜增生150例患者随机分组,丙氨瑞林组(治疗组)肌肉注射丙氨瑞林150μg,qd,连续3月;炔诺酮组(对照组)口服炔诺酮5mg,qd,每月22天,持续3个月。观察用药前后子宫内膜的转化情况以及ER、PR、GnRHR的变化。结果丙氨瑞林组增生内膜的转化率为95.5%,炔诺酮组增生内膜的转化率为66.7%,两组转化率比较,P<0.05。两组用药前后ER、PR和GnRHR表达均无差异(P>0.05)。结论丙氨瑞林对3种子宫内膜增生均有转化作用,其中对单纯增生型子宫内膜的转化最好,并且丙氨瑞林治疗单纯增生型子宫内膜的疗效明显优于炔诺酮,但丙氨瑞林治疗子宫内膜增生3个月,对ER、PR和GnRHR无明显的调节作用。更多还原

【Abstract】 Objective:To evaluate the therapy effect of Alarelin on endometrial hyperplasia and whether it regulates ER,PR or GnRHR.Methods:150 patients with diagnosed by pathology were randomized divided into two groups. Alarelin 150ug/d was given to study group and norethisterone 5mg/d,22 days every months was given to control group.All patients were treated for 3 months. Then the endometrial transformation and the change of ER,PR and GnRHR between before and after theropy were observed.Results:In study group the transformation of endometrial hyperplasia was 95.5%; and in control group was 66.7%.Comparing the transformation of these two groups, P<0.05.There was no difference of the expression of ER,PR or GnRHR after treated with Alarelin and norethisterone.Conclusion:Alarelin can transform the three kinds of endometrial hyperplasia, especially for simple hyperplasia, and it excels distinctly norethisterone in transformation of simple hyperplasia. Alarelin doesn’t have apparent regulation effect of ER,PR and GnRHR after three months of therapy to endometrial hyperplasia.更多还原