【摘要】 目的:探讨IGF-Ⅱ在子痫前期发病机制中的作用。方法:用免疫组织化学方法检测正常晚孕组和轻度、重度子痫前期患者胎盘组织中IGF-Ⅱ的表达,同时用ELISA方法检测3组研究对象胎儿脐血中IGF-Ⅱ的含量。结果:IGF-Ⅱ在脐血中的含量,重度子痫前期组显著高于轻度子痫前期组(P<0.001),轻度子痫前期组显著高于正常晚孕组(P<0.01);IGF-Ⅱ在胎盘组织中的表达,重度子痫前期组显著低于轻度子痫前期组(P<0.01),轻度子痫前期组显著低于正常晚孕组(P<0.01)。结论:子痫前期时脐血IGF-Ⅱ含量升高可能是子痫前期病理变化的结果,而胎盘组织中IGF-Ⅱ表达减少可能是引发子痫前期的重要因素之一。更多还原

【Abstract】 Objective:To explore the effect of insulin-like growth factor-Ⅱ(IGF-Ⅱ) on the pathogenesis of preeclampsia.Methods:The umbilical serum IGF-Ⅱ levels in twenty one normal pregnancy and ninety-tree preeclamptic patients was detected by ELISA;The expression of IGF-Ⅱ in placental tissue was measured by immunohistochemistry SP.Results:The content of IGF-Ⅱ in umbilical serum was significantly higher in severe preeclampsia group than that of mild preeclampsia group (P<0.001) and that of mild preeclampsia group were obviously higher than that of normal pregnancy group(P<0.01);The expression of IGF-Ⅱ in severe pregnancy placentas were obviouslyly lower than that of mild preeclampsia group(P<0.01) and both were significantly lower than that of normal group(P<0.01).Conclusion:The IGF-Ⅱ level in placentas could be a key factor involved in the pathogenesis of preeclampsia;and the content of IGF-II in umbilical serum could be the result of pathogenesis of preeclampsia.更多还原