Objective:To explore the effect of insulin-like growth factor-Ⅱ(IGF-Ⅱ) on the pathogenesis of preeclampsia.Methods:The umbilical serum IGF-Ⅱ levels in twenty one normal pregnancy and ninety-tree preeclamptic patients was detected by ELISA;The expression of IGF-Ⅱ in placental tissue was measured by immunohistochemistry SP.Results:The content of IGF-Ⅱ in umbilical serum was significantly higher in severe preeclampsia group than that of mild preeclampsia group (P<0.001) and that of mild preeclampsia group were...