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COX-2对子宫内膜异位症血管内皮生长因子及血管形成的影响
The effects of COX-2 exprssion on VEGF and angiogenesis in endometriosis
【摘要】 目的:探讨环氧化酶-2(COX-2)和血管内皮生长因子(VEGF)在子宫内膜异位症(EM s)组织中的表达,以及COX-2对VEGF及血管形成的影响。方法:采用免疫组织化学法对45例EM s患者组织中COX-2和VEGF的表达进行检测。结果:45例EM s患者组织中COX-2和VEGF的阳性表达率分别为62.2%和51.1%,较正常子宫内膜的表达明显增高(P<0.001)。EM s内膜中的COX-2和VEGF在增殖期和分泌期分别为64.0%、60.0%和52.0%、50.0%,差异不显著(P>0.05)。COX-2表达与VEGF的表达显著相关(r=0.585,P<0.01)。结论:COX-2和VEGF在EM s组织中存在高表达,二者在血管生成过程中密切相关,COX-2可能通过增加VEGF表达而促进EM s的血管形成,从而在EM s的发生、发展中起关键的作用。
【Abstract】 Objective:To investigate the expression of cyclooxygenase-2(COX-2) and vascular endothelial growth factor(VEGF) in endometriosis and the effects of COX-2 expression on VEGF and angiogenesis in endometriosis,and to probe the possible mechanism of their association.Methods:The expression of COX-2 and VEGF in 45 cases of endometriosis patients was detected by immunohistochemistry methods.Results:The expression of COX-2 and VEGF in endometriosis was 62.2% and 51.1%,respectively,which was significant higher than that of normal endometriosis(P<0.001).COX-2 and VEGF of the endometrium of endometriosis patients in proliferative phase and secretary phase were 64.0%,60.0% and 52.0%,50.0%.The expression of COX-2 was closely correlated with that of VEGF(r=0.585,P<0.01).Conclusion:COX-2 and VEGF over expression is found in EMs tissue.It is possible that COX-2 may stimulate angiogenesis through VEGF up-regulation.COX-2 may play a key role in endometriosis.
【Key words】 Endometriosis; Cyclooxygenase-2; Vascular endothelia growth factor;
- 【文献出处】 中国妇幼保健 ,Maternal and Child Health Care of China , 编辑部邮箱 ,2006年06期
- 【分类号】R711.71
- 【被引频次】6
- 【下载频次】131