【摘要】 目的评价局部亚低温治疗急性脑梗死的临床疗效。方法本研究为随机、配对对照的临床研究。符合入选标准的62例患者分为2组:对照组仅接受尿激酶100万U溶栓治疗,低温组在尿激酶100万U溶栓治疗的同时加用局部亚低温治疗。采用欧洲卒中量表(ESS)评价神经功能缺失状态。结果发病3h内给予溶栓治疗的低温组患者在溶栓后7d始ESS评分显著高于对照组患者。发病3~6h给予溶栓治疗的低温组患者在溶栓后24h始ESS评分显著高于对照组患者。结论局部亚低温并用溶栓治疗的效果优于单用溶栓治疗,局部亚低温治疗急性闭塞性脑血管病安全有效。更多还原

【Abstract】 Objective To evaluate the efficacy of selective and mild hypothermia for acute cerebral infarctions.Methods A randomized and paired clinical study was performed.62 Patients consistent with the inclusion criteria were randomized into 2 groups:hypothermia group,receiving selective and mild hypothermia combined with unokinase(UK)1.0 MU and control group,receiving UK 1.0 MU only.European Stroke Scale(ESS)was used to evaluate the neurological functions.Results As intravenous thrombolytic therapy within 3h after the onset,the ESS scores examined 7 days after thrombolysis in hypothermia group was significantly higher than those in control group.As intravenous thrombolytic therapy during 3h to 6h after the onset,the ESS scores of hypothermia group increased more remarkably from 24h after thrombolysis than those in control group.Conclusion Selective and mild hypothermia combined with UK is more effective than UK for acute cerebral infarctions.Selective and mild hypothermia is effective and relatively safe in the treatment of acute ischemic cerebral vascular disease.更多还原