【摘要】 目的研究茯苓P oria cocos的化学成分,从中寻找有重要生物活性及药用前景的天然产物。方法采用正相硅胶,反相RP-18,Sephadex LH-20及M C I等柱色谱分离化合物,运用波谱技术分析确定化学结构。结果从茯苓的提取物中共分离并鉴定了13个化合物,经波谱分析确定分别为:麦角甾-7,22-二烯-3β-醇(Ⅰ)、胡萝卜苷(Ⅱ)、茯苓酸(Ⅲ)、3β-乙酰基-16α-羟基-羊毛甾-7,9(11),24(31)-三烯-21-酸(Ⅳ)、3,β16α-二羟基-羊毛甾-7,9(11),24(31)-三烯-21-酸()、16α-羟基-3-羰基-羊毛甾-7,9(11),24(31)-三烯-21-酸()、3β-羟基-羊毛甾-7,9(11),24-三烯-21-酸()、3β-对羟基苯甲酸去氢土莫里酸()、3β,16α-二羟基-羊毛甾-7,9(11),24-三烯-21-酸()、乙基-β-D-吡喃葡萄糖苷()、L-尿苷()、柠檬酸三甲酯()、(R)-苹果酸二甲酯()。结论化合物和~均为首次从该植物中分离得到。更多还原

【Abstract】 Objective To study the chemical constituents from Poria cocos aiming at searching for bioactive natural products. Methods All compounds were isolated by repeated SiO₂,LH20,MCI,and RP-18 column chromatography.Their structures were determined by various spectral methods.Results Thirteen compounds were isolated from P.cocos and their structures were identified by means of spectroscopic analysis as: ergosta-7,22-diene-3β-ol（Ⅰ）;daucosterol （Ⅱ）;pachymic acid（Ⅲ）;3β-acetyloxy-16α-hydroxylanosta-7,9（11）,24（31）-trien-21-oic acid（Ⅳ）;3β,16α-dihydroxy-lanosta-7,9（11）,24（31）-trien-21-oic acid（Ⅴ）;16α-hydroxy-3-oxo-lanosta-7,9（11）,24（31）trien-21-oic acid（Ⅵ）;3β-hydroxylanosta-7,9（11）,24-trien-21-oic acid（Ⅶ）;3β-p-hydroxybenzoyl-dehydrotumulosic acid（Ⅷ）;3β,16α-dihydroxylanosta-7,9（11）,24-trien-21-oic acid（Ⅸ）;ethyl-βD-glucopyranoside（Ⅹ）;L-uridine（Ⅺ）;trimethyl citrate（（ⅩⅡ））;and（R）-dimethyl malate（（ⅩⅢ））.Conclusion Compounds Ⅱ and Ⅹ-（ⅩⅢ） are found for the first time in P.cocos.更多还原