【摘要】 目的分析神经梅毒的临床特征和早期诊断依据。方法对12例神经梅毒患者的临床资料进行了回顾性分析。结果5例有症状神经梅毒既往未接受驱梅治疗,临床表现多样。7例无症状神经梅毒接受首次驱梅治疗的时间较迟,表现为血清固定或血清复发。10例在治疗后1~6月复查脑脊液的各项指标,白细胞计数和蛋白含量均下降或转阴,而脑脊液(CSF)-VDRL试验仅2例转阴。结论未能早期发现和治疗梅毒是导致神经梅毒的重要因素。神经梅毒的诊断目前尚无金标准。脑脊液白细胞计数与蛋白含量是监测神经梅毒疗效的较敏感指标。更多还原

【Abstract】 Objective To study the clinical features of neurosyphilis and to find clues for early diagnoses.Methods Clinical data of 12 cases were analyzed.Results 5 cases with neurologic symptoms hadn’t been treated once,their clinical manifestations were variable.7 cases of asymptomatic neurosyphilis got their initial treatment very late,and exhibited serofast state or serologic relapse.The white-cell count and protein of cerebrospinal fluid(CSF) decreased or turned negative among 10 cases after treatment,wheras 2 cases of CSF-VDRL was negative.Conclusion The failure to be diagnosed and treated early is the important cause of neurosyphilis.There is no golden standard available now in diagnosing neurosyphilis.The white-cell count and protein of cerebrospinal fluid are sensitive in evaluating the efficiency of treating neurosyphilis.更多还原