【摘要】 目的观察局部注射透明质酸钠(SH)或透明质酸酶(HD)治疗晚期限局性硬皮病(ASC)的临床效果,并进行比较分析。方法选取ASC患者,随机分成SH治疗组和HD治疗组,SH治疗组直接局部注射SH;HD治疗组用HD加利多卡因局部注射,然后分析比较两组的临床效果。结果SH治疗组有效率9 0.9 1%,显著高于HD治疗组(45.45%,P<0.05),且不良反应少而小。结论首次提出SH可能是治疗ASC的有效药物。这可能与SH抑制成纤维细胞生长、抑制其胶原分泌、促进胶原分解及抗炎症等作用有关。更多还原

【Abstract】 Objective To compare the curative effects of sodium hyaluronate(SH) or hyaluronidase(HD) to treat the patients with advanced scleroderma circumscriptum(ASC).Methods SH,or HD bound with 2% lidocaine was injected into local lesions of 11 ASC patients,respectively.The symptoms before and after treatment were observed and compared.Results The effective rate 90.91% of SH used to treat patients with ASC was higher than that 45.45% of HD significantly(P<0.05).The side effects of SH were mild.Conclusion It is put forward for the first time that SH may be a potent medicine to treat ASC.The relative mechanisms may be that SH can inhibit the proliferation of fibroblast and the secreting of collagenous fiber,accelerate the decomposing of collagenous fiber,and counteract inflammation.更多还原