【摘要】 目的:研究骨质疏松症与血清瘦素和转化生长因子β(TGF-β)浓度的关系。方法:酶联免疫吸附法(ELISA)检测24例骨质疏松症患者血清中瘦素和TGF-β水平,并与正常人对照;计算血清瘦素、TGF-β与骨密度的相关性。结果:骨质疏松症患者TGF-β水平较对照组明显降低(P<0.05),但血清瘦素与对照组无显著差异(P>0.05)。血清TGF-β与骨密度呈正相关,瘦素与骨密度无相关性。结论:TGF-β水平降低可能是骨质疏松症发病的原因之一,而无直接证据表明瘦素水平变化与骨质疏松症发病有相关性。更多还原

【Abstract】 Objective To explore the relationship between osteoporosis and leptin and transforming growth factor β(TGF-β) levels.Methods Serum leptin and TGF-β in 24 patients with osteoporosis were measured by ELISA,and compared with that in 24 healthy subjects as control.Results The serum TGF-β in the patients with osteoporosis was significantly lower than that in healthy subjects.however,there was no significant difference in serum leptin between patients and healthy subjects.The serum TGF-β was positively correlated with bone mineral density.However,there is not correlation between serum leptin and bone mineral density.Conclusion The decreased level of TGF-β may be one of the causes to precipitate osteoporosis,but there is no direct evidence demonstrating the change of serum leptin is correlated with the pathogonesis of osteoporosis.更多还原