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甘薯花青苷色素的抗氧化活性及抑肿瘤作用研究

STUDY ON THE ANTIOXIDANT ACTIVITY OF SWEET POTATO ANTHOCYANIN AND ITS INHIBITING EFFECT ON GROWTH OF CANCER S180

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【作者】 王关林岳静苏冬霞方宏筠

【Author】 WANG Guan-lin, YUE Jing , SU Dong-xia, FANG Hong-jun (College of Life Science, Liaoning Normal University, Dalian 116029,China)

【机构】 辽宁师范大学生命科学学院辽宁师范大学生命科学学院 大连116029大连116029

【摘要】 目的:为在食品中应用甘薯花青苷色素(SPAC),研究其抗氧化活性及抑肿瘤作用。方法:采用体外实验测定SPAC清除??O2和?OH及抑制丙二醛(MDA)生成的能力。测定SPAC对小鼠血清及皮肤超氧化物歧化酶(SOD)活性、抑制S180生长和血谷胱甘肽过氧化物酶(GSH-Px)活性与MDA生成的作用。结果:在体外实验中SPAC能清除??O2和?OH,与同浓度VC相比,清除率分别提高30.63%和20.57%;小鼠灌胃SPAC后的血清和皮肤细胞中SOD活力分别提高27.30%和13.50%;SPAC对小鼠肉瘤S180有抑制作用,最高抑瘤率达到43.12%;与对照组相比,在用SPAC的抑瘤组小鼠血清中GSH-Px和SOD活性明显提高,MDA降低。结论:SPAC具有抗氧化及抑肿瘤作用,在食品和化妆品中有开发潜力。

【Abstract】 Objective: To study the antixiodant activity of sweet-potato anthocyanin (SPAC) and its inhibiting effect on growth of cancer S180. Method: The scavenging capacity of ??O2 and·OH and the inhibitory effect of MDA were determined in vitro.The SOD activity of serum and skin, the effect on S180 growth, serum GSH-Px activity and MDA were tested in mice. Results: SPAC had antioxidant activity in vitro, with elimination rate of O2?? and·OH 30.63% and 20.57% higher than the same concerntration of VC respectively. Activity of SOD in the serum and skin of mice were raised 27.30% and 13.50% respectively after giving SPAC. The growth rate of cancer S180 in the mice was inhibited, and the highest inhibitory rate was 43.12%. The activity of serum GSH-Px, SOD of the mice was raised as compared to control, but MDA declined . Conclusion: SPAC is a perfect natural pigment with inhibitory effect on growth of cancer S180 probably through its antioxidant activity.

【关键词】 甘薯花青甘色素抗氧化抑肿瘤
【Key words】 sweet potatopigmentantioxidantinhibiting cancer
【基金】 辽宁省政府科技攻关项目(No.97064)
  • 【文献出处】 营养学报 ,Acta Nutrimenta Sinica , 编辑部邮箱 ,2006年01期
  • 【分类号】R151
  • 【被引频次】113
  • 【下载频次】630
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