【摘要】 目的制备肠镜糊制剂,并建立其质量控制方法。方法采用甘油浸泡羧甲基纤维素钠(CMC-Na)制备肠镜糊,采用紫外分光光度法测定该制剂中盐酸丁卡因的含量,检测波长为310 nm。结果该制备法缩短了CMC-Na的溶胀时间;盐酸丁卡因浓度在2~10μg.mL-1范围内呈现良好线性关系,r=0.998 7(n=5)。平均回收率99.61%,RSD=0.54%。结论该制备方法简单,含量测定方法简便、快速、准确。更多还原

【Abstract】 Objective To prepare an enteroscope paste and to set up a method for its quality control. Methods In the process of preparation of the parte,glycerin insterd of water was used to soak the sodium carboxymethyl cellulose（CMC-NA）.The content of tetracaine hydrochloride in the paste was determined with UV spectrophotometry at a wavelength of 310 nm. Results The swelling time of CMC-Na is shortened as compared with that in the traditional method.The standard curve of tetracaine hydrochloride was linear over the concentration range of 2～10 μg· mL^-1,r= 0.998 7（n=5）.The average recovery rate was 99.61%,RSD = 0.54%. Conclusion The method was handy,quick and the content determination was accurate.更多还原