【摘要】 目的探讨小剂量长春瑞滨(NVB)对局部晚期非小细胞肺癌的放射增敏作用和不良反应。方法放射治疗的非小细胞肺癌60例,随机分为治疗组和对照组各30例。两组患者均先给予两个周期的NP方案[NVB 25mg.(m2)-1,第1,8天;顺铂30 mg.(m2)-1,第1~3天]诱导化学药物治疗,3周为1周期;第2周期结束后2周开始放疗,采用常规分割,6~15 MVX射线,总量60 Gy/30次,6周完成。治疗组在放疗期间加用NVB增敏治疗,NVB 6mg.(m2)-1,每周星期二、星期四各1次。两组患者放疗结束后1周开始再用NP方案化疗2个周期。结果近期疗效:治疗组完全缓解13.3%。部分缓解60.0%,总有效率73.3%。对照组完全缓解10.0%,部分缓解56.7%,总有效率66.7%。两组比较差异无显著性(P>0.05)。1,2,3 a的生存率,治疗组分别为66.3%,36.7%和23.3%,对照组分别为46.7%,26.7%,16.6%。两组比较无显著差异(P>0.05)。结论小剂量长春瑞滨对局部晚期非小细胞肺癌有放射增敏作用,但不能提高生存率。更多还原

【Abstract】 Objective To probe into the radiosensitizing effect and adverse reactions of low-dose navelbine（NVB） in the treatment of locally advanced non-small cell cancer of the lung（NSCLC）. Methods 60 patients with locally advanced NSCLC were randomly divided into two equal groups,the trial group and control group.Prior to radiotherapy,patients of both groups were subjected to 2 cycles of induction chemotherapy each of which lasting 3 weeks.In each of the 2 cycles,the patients were given each 25 mg·(m²)^-1of NVB on day 1 and 8,30 mg·(m²)^-1 of cisplatin from the 1^st to 3^rd day,according to the NP program.The radiotherapy was started up 2 weeks after the termination of the 2^nd cycle of induction chemotheraphy.Routine fractionation method was used.The patients were given each a total dose of 6-15 MVX ray DT 60 Gy divided into 30 fractionations administered successively in a period of 6 weeks.During the course of radiotherapy,patients of the trial group were given each additionally 6 mg·(m²)^-1 of NVB on each Tuesday and Thursday.One week after the termination of ratiotherapy,patients of both groups were once more subjected to 2 cycles of induction chemotheraphy according to the NP program. Results Short-term therapeutic effectiveness: the rates of complete remission and partial remission as well as the overall effective rates in patients of the trial group and control group were 13.3%,60.0% and 73%,and 10.0%,56.7% and 66.7%,respectively,the differences between the 2 groups being significant（P<0.05）.The 1,2 and 3 year survival rates in patients of the trial group and control group were 66.3%,36.7% and 23.3%,and 46.7%,26.7% and 16.6%,respectively,the differences between the 2 groups being insignificant（P>0.05）. Conclusion Low-dose navelbine was shown to have radiosensitizing effects in the treatment of patients with locally advanced NSCLC,but it could not increase the survival rate of the patients.更多还原