【摘要】 目的制定痔疮栓的质量标准。方法采用薄层色谱法对栓剂中的大黄、柿蒂进行定性鉴别;采用化学法对栓剂中的冰片、芒硝进行定性鉴别;采用高效液相色谱外标法对大黄素进行含量测定。结果样品浓度在4~20μg.mL-1范围内,浓度与峰面积有良好的线性关系,重现性RSD=0.35%,稳定性RSD=0.50%,平均加样回收率为99.19%(n=6)。结论该方法简单、方便、准确,可作为痔疮栓质量控制的方法。更多还原

【Abstract】 Objective To establish a quality standard for haemorrhoids suppository. Methods Radix et rhizoma rhei and calyx kaki in haemorrhoids suppository were identified by thin-layer chromatography（TLC）.Camphol and sodiam sulfate in the Suppository were qualitativerly identified with chemical methods.The content of Rheum emodin was determined by HPLC. Results Within the range of sample concentration 4-20 μg·mL^-1,there was a good linear relationship between the concentration and the peak area;the RSD of reproducibility and stability were 0.35%,0.50% respectively,and the average recovery rate was 99.19%（n=6）. Conclusion This method is easy,convenient and precise, so it can serve as a quality control method for haemorrhoids suppository.更多还原