【摘要】 目的研究稳心颗粒对缺血性心肌病型冠心病患者室性和室上性早搏、左心室收缩舒张功能及运动耐量的影响。方法缺血性心肌病型冠心病患者106例,随机分为实验组(55例)和对照组(51例),对照组按常规进行降脂、抗凝、抗心律失常、改善心肌供血、优化心肌能量代谢等治疗,实验组在按照对照组常规治疗的基础上加用稳心颗粒口服,疗程4周。在治疗前后对患者进行24小时动态心电图、超声心动图检查,并测试患者6分钟步行距离(6MWD)。结果实验组在控制室上性早搏(总有效率90.9%vs64.7%,X2=10.69,P<0.01)和室性早搏(总有效率89.6%vs66.7%,X2=7.06,P<0.01)、提高左心室射血分数(总有效率78.0%vs53.8%,X2=5.24,P<0.05)、提高患者运动耐量等方面的疗效均显著优于对照组。结论在常规治疗的基础上合用稳心颗粒能够进一步改善缺血性心肌病型冠心病患者的早搏治疗效果,提高左心室射血分数,更有效地控制,并提高患者的运动耐量。更多还原

【Abstract】 Objective To evaluate the therapeutical effect of Wenxinkeli to ischemic cardiomyopathical coronary heart disease by observation ventricular and supraventricular extrasystole,left ventricular contraction and diastolic function a well as exercise tolerance.Methods 106 ischemic cardiomyopathical coronary heart disease patients were randomly divided into experimental group, (EG, n=55)and control group(CG, n=51). Therapy such as cholesterol control, anticoagulation, antiarhythmia, improvement heart blood supply, optimization heart energy metabolism were given routinely. And the EG accepted an additional Wenxinkeli treatment (9grams p.o. tid for 4 weeks). When beginning and termination the treatment, Holter and ultrasonic echocardiography were performed,and 6-minute walking distance (6MWD) was recorded.Results Compared with CG, EG presentation significant better effect on decrease supraventricular(total effective rate 90.9% vs 64.7%,X~2=10.69,P<0.01) and ventricular (total effective rate 89.6% vs 66.7%,X~2=7.06,P<0.01) extrasystole, increase left ventricular ejection fraction (LVEF) (total effective rate 78.0% vs 53.8%,X~2=5.24,P<0.05), and improve patients’exercise tolerance.Conclusion Additional Wenxinkeli administration based on routing treatment, is benefit to ischemic cardiomyopathical coronary heart disease patients, for effect on decrease supraventricular and ventricular extrasystole, increase LVEF and improve exercise tolerance.更多还原