护肝片防治抗结核药物肝损害的临床观察

【摘要】 目的观察护肝片对抗结核药物所致肝损害的防治效果。方法初治肺结核168例,应用2HRZE(S)/4HR抗结核治疗,治疗组88例,全程加服护肝片;对照组80例,全程加服葡醛内酯片。结果治疗组出现肝损害6例(6.82%),其中HBsAg阳性患者出现5例(5.68%);对照组出现肝损害26例(32.50%),其中HBsAg阳性患者出现20例(25.00%)。两组比较有显著性差异(P<0.01)。HBsAg阳性患者在抗结核治疗中肝功能更容易受损害。结论护肝片在防治抗结核药物所致肝损害的发生是有效的,特别是对HBsAg阳性的结核病患者。更多还原

【Abstract】 Objective To determine the effect of Hu- Ganpian tabelets in preventing and treating liver damage caused byanti- tuberculosis drugs. Methods 168 initially- treated pulmonary tuberculosis patients who received the regimen of2HRZE (S)/4HR were randomly separated into 2 groups :Observe group,88 cases,supplemented with Hu- Ganpiantabelets for 6 months and Control group,80 cases,received glucurolactone. Results There were 6 cases who had liverdamage in observe group (6.82%),5 cases with HBsAg positive(5.68%);There were 26 cases who had liver damage in con-trol group (32.50%),20 cases with HBsAg positive(25.00%).There were significant difference between the 2 groups(P<0.01). HBsAg positive patients were more likely to have liver damage in anti- tuberculosis treatment. ConclusionsHu- Ganpian tabelets is effective in preventing and treating liver damage caused by anti- tuberculosis drugs, HBsAg pos-itive patients’ liver function should be monitored in the early period of anti- tuberculosis treatment.更多还原