【摘要】 大电导钙激活钾通道广泛分布于人体组织,在平滑肌上尤为丰富。它在维持血管平滑肌细胞静息膜电位,调节平滑肌舒缩方面起着重要作用,并与高血压有着不容忽视的联系,但其联系机制迄今尚有争议。而一些药物能促进该通道的开放,于是对临床工作具有相当的指导意义。本文就近年来关于该通道的结构特征,动力学特征,与高血压的联系及其通道开放剂等方面的研究进展简要综述。更多还原

【Abstract】 High-conductance calcium-activiated potassium channels are generally distributed all over the body tissue,especially the smooth muscle.They play an important part in maintaining the resting membrane potential of vascular smooth muscle and regulating its systalitic action,which has an close relationship with hypertention although their mechanism is still under disputing.Otherwise,they could be opened by some medicine,which may have instructive significance to the clinical work.In this review,we summarized the study of this channel about its structure,dynamic character,its relationship with hypertension and itschannel opener.更多还原