【摘要】 新生血管生成不仅为肿瘤组织提供营养支持,而且是肿瘤细胞进入循环系统的途径。CD105仅在激活的上皮细胞表达；VEGF-C为重要的血管生成因子之一,但二者与肝癌转移是否存在关联尚不明晰。探讨CD105及VEGF-C表达与肝癌肝内转移的关联。构建承栽37例肝癌及癌旁组织的组织微阵列,免疫组织化学方法检测CD105及VEGF-C的表达。存在肝内转移的肝癌组织MVD-CD105均值为28.4±19.4,而无肝内转移的肝癌组织MVD-CD105均值为5.4±5.2,差异显著(P＜0.01)；VEGF-C在存在肝内转移的肝癌组织表达率为46.15%(6/14),无肝内转移的肝癌组织中表达率为41.67%(10/24),二者无显著差异。MVD-CD105分值与肝癌肝内转移密切相关；血管生成可能在肝癌肝内转移过程中起重要作用。更多还原

【Abstract】 Neovascularization provides not only the route for nutrient supply to the tumor but also the conduit for tumor cells to shed into the circulation.CD105 expressed only on active endothelia cells;VEGF-C served as an important member of VEGF family, but whether there were any link between expression of CD105 and VEGF-C and metastasis in HCC still remains unclear.To clari- fy whether the expression of CD105 and VEGF-C were related to the metastasis in HCC,the MVD of CD105 and the expression of VEGF-C were detected in a HCC tissue microarry by histochemestry.A tissue microarry containing 37 HCCs and adjacent non -tumorous liver tissue samples was constructed.The expression of CD105、VEGF-C were detected by histochemestry.The mean score of MVD-CD105 was 28.4±19.4 in HCC with intrahepatic metastasis,whereas 5.4±5.2 in HCC without intra- hepatic metastasis(P＜0.01);Positive expression of VEGF-C in HCC with and without intrahepatic metastasis was 46.15%(6/ 14)and 41.67%(10/24)respectively,no significant difference was show between them.The score of MVD-CD105 was closely related to intrahepatic metastasis;Angiogenesis might play important role in intrahepatic metastasis.更多还原