【摘要】 目的研究喉鳞癌组织中人乳头状瘤病毒(humanpapillomavirus,HPV)16/18亚型的感染情况并进行临床分析。方法应用原位杂交法分别检测39例喉鳞癌组织,10例声带息肉组织中HPV16/18亚型的感染情况,并分析喉鳞癌组织中HPV16/18阳性感染与肿瘤各项临床病理参数的关系。结果39例喉鳞癌组织中HPV16/18阳性率为48.7%(19/39)。10例声带息肉组织中均未见HPV16/18感染(0/10)。HPV16/18在喉鳞癌组织与声带息肉组织中的表达差异经χ2检验有统计学意义。喉鳞癌组织中HPV16/18感染与癌组织的的组织学分级、临床分期、淋巴结转移间经Fisher′s精确概率法χ2检验均未见相关性。结论喉鳞癌的发生与HPV16/18感染相关。更多还原

【Abstract】 Objective To investigate the correlation between human papillomavirus(HPV) 16/18 subgroup infection and laryngeal squamous cell carcinoma(LSCC).Methods The infection of HPV16/18 in 39 laryngeal carcinoma specimens and 10 vocal cord polyp specimens were detected by in situ hybridization. Results The positive rate of HPV16/18 expression in 39 laryngeal carcinoma specimens was 48.7%(19/39). The positive rate of HPV16/18 subgroup expression in 10 vocal cord polyps was 0(0/10) . Statistical test showed that HPV16/18 subgroup infection was significantly higher in LSCC than that in vocal cord polyps. No statistically association was observed among the frequency of HPV16/18 subgroup infection and TNM stages, degree of differentiation or lymph nodes metastases. Conclusions HPV 16/18 subgroup infection is associated with he pathogenesis of LSCC.更多还原