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Syntheses, Characterization and Antitumour Activities of Rare Earth Metal Complexes with 2-(((4,6-dimethyl)-2-Pyrimidinyl)thio)-Acetic Acid

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【Author】 Qu Jianqiang 1, 2, Wang Liufang 1, Liu Yingqi 1, Song Yumin 3, Wang Yinyue 1, Jia Xiaofei 2(1. State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China; 2. Department of Chemistry, School of Science, Tianjin University, Tianjin 300072, China; 3. College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China)

【机构】 State Key Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou 730000 China Department of Chemistry School of Science Tianjin University Tianjin 300072 China； State Key Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou 730000 China； College of Chemistry and Chemical Engineering Northwest Normal University Lanzhou 730070 China； Department of Chemistry School of Science Tianjin University Tianjin 300072 China；

【Abstract】 Eight rare earth metal （Ⅲ） complexes with 2-（（（4,6-dimethyl）-2-pyrimidinyl）thio）-acetic acid, LnL₃·nH₂O [HL=2-（（（4,6-dimethyl）-2-pyrimidinyl）thio）-acetic acid; Ln=La, Ce, Pr, Nd, Sm Eu, Gd, Tb; n=4 or 5], were prepared and characterized by elemental analysis, complexometric titration, thermal analysis, conductivity, IR and 1H-NMR. The results reveal that carboxyl group of the ligand coordinates with rare earth ions in bidentate mode after deprotonated. The water molecules exist as crystal water in the complexes. The anti-tumour activities of HL and some complexes were tested by both the MTT and SRB methods. The results show that the suppression ratios of some complexes against the tested tumour cells （HL-60 human leukemia cell lines, BGC-823 human gastric carcinoma cell lines, hela human cervix adenocarcinoma cell lines and Bel-7402 human hepatic carcinoma cell lines） are superior to HL.更多还原

【关键词】 2-(((4,6-dimethyl)-2-pyrimidinyl)thio)-acetic acid； complexes； anti-tumour activities； rare earths；
【Key words】 2-(((4,6-dimethyl)-2-pyrimidinyl)thio)-acetic acid； complexes； anti-tumour activities； rare earths；

【基金】 ProjectsupportedbytheNationalNaturalScienceFoundationofChina(50272027)andthe985ScienceFoundationofTianjinUniversity

【文献出处】 Journal of Rare Earths ,稀土学报(英文版) , 编辑部邮箱 ,2006年01期

【分类号】O627.3
【被引频次】6
【下载频次】56

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