【摘要】 目的:观察缬沙坦对原发性高血压(EH)患者的降压作用和对左室肥厚(LVH)的影响。方法:58例EH患者(其中有LVH者32例),口服缬沙坦80~160mg/d,共8个月。观察血压、不良反应,治疗前后测血脂、血糖及肝肾功能,并行超声心动图检查。结果:EH患者经缬沙坦治疗后收缩压、舒张压均有显著下降(P<0.01),其中有LVH者左心室舒张末期内径(LVDd)及左室重量均有明显下降(P<0.05),舒张末期左室后壁厚度(LVPWd)、室间隔厚度(IVSd)及左室重量指数(LVMI)也有明显下降(P<0.01)。结论:缬沙坦在降压的同时可逆转LVH,且安全、有效。更多还原

【Abstract】 Objective: To study the effect of valsartan on left ventricular hypertrophy in patients with essential hypertension.Methods:58 essential hypertensive patients,including 32 patients with left ventricular hypertrophy were given valsartan orally 80～160 mg per day for eight months.Left ventricular diameter and left ventricular mass index were measured by echoardiography.Results: Systolic blood pressure,diastolic blood pressure significantly decreased (P<0.01).The left ventricular diastolic diameter and left ventricular weight decreased obviously(P<0.05)meanwhile the data of LVPWd,IVSd and LVMI were significantly brought down after Valsartan therapy(P<0.01).Conclusion: Valsartan is an effective drug to reverse left ventricular hypertrophy.更多还原