【摘要】 目的:建立同时测定萘普生的含量及有关物质的高效液相色谱法。方法:色谱柱采用C18柱(ZORBAXC18,4.6mm×150mm,5μm),流动相为乙腈-水-冰醋酸(50491),检测波长为254nm。结果:本法的平均回收率为94.9%,相对标准偏差为0.15%,在5~45μg/ml的浓度范围之间呈线性。结论:本法可同时测定萘普生含量及其有关物质含量,且简便、灵敏、准确。更多还原

【Abstract】 Objective: To develop a HPLC method for determination of content of naproxen and its related substances in naproxen colored tablets. Method: The separation was performed on a ZORBAX C18 Column (4.6 mm×150 mm ,5 μm )with acet onitrile-water-glacial acetic acid (50:49:1) as mobile phase. The [CM(42]detection wavelength was set at 254 nm. Result: The average recovery of naproxen using this method was [CM)] 94.9%. RSD was 0.15% .Results of this method showed linear correlation in the range of 5～45 μg /ml. Conclusion: The HPLC method developed is simple, sensitive and accurate. It can be used for determination of content of naproxen and its related substances in naproxen colored tablets.更多还原