【摘要】 目的:介绍引起QT间期延长及尖端扭转型室性心动过速(简称室速)的非心血管药物的种类和致病机制,以引起临床医生的重视。方法:对国内外相关文献进行综合、归纳。结果:许多非心血管药物可引起QT间期延长及尖端扭转型室速,包括抗微生物药、抗组胺药、三环类抗抑郁药、抗精神病药和胃肠动力药等。结论:了解导致这种较为罕见且严重的心律失常药物的种类及发病机制,对预防和正确治疗极为重要。更多还原

【Abstract】 Objective: To introduce the pathogenesis of QT prolongation and torsades de pointes(TDP) induced by noncar-diovascular drugs and the classes of the drugs. Methods: The newest related literature at home and abroad was collected and summarized. Results: Many noncardiovascular drugs could cause QT prolongation and TDP, including antimicrobials, antihis-tarainics, tricyclic antidepressants, antipsychotics and gastrointestinal kinetogenic drugs, etc. Conclusion: It is important to be aware of the classes of drugs causing TDP and their pathogenic mechanism, which may be helpful to make an appropriate treatment strategy.更多还原