【摘要】 目的探讨急性胰腺炎(AP)患者血浆凝血功能的变化及其临床意义。方法收集2001年1月~2003年6月,福建省立医院128例住院AP患者资料。检测凝血酶原时间(PT)、凝血酶原时间国际标准化指数(INR)、部分活化凝血酶原时间(APTT)和纤维蛋白原浓度(FIB)。结果重症急性胰腺炎组(SAP)的PT、APTT、INR和FIB与轻症急性胰腺炎组(MAP)比较有显著性差异(P<0.01);多器官功能障碍综合征(MODS)组与无MODS组比较有显著性差异(P<0.01);合并胆源性病变组和非胆源性AP组比较无显著性差异(P>0.05);在出现器官功能衰竭患者中有肝功能衰竭与无肝功能衰竭者相比,差异无显著性(P>0.05)。MAP组PT、APTT、FIB值和Ranson积分之间无直线相关关系(P>0.05);但SAP组和MODS组PT、APTT、FIB值和Ranson积分之间均存在直线相关关系(P<0.01)。结论AP患者血浆凝血功能障碍可提示与患者预后有关。更多还原

【Abstract】 Objective To evaluate clinical significance of coagulation function change in acute pancreatitis (AP). Methods Data were analyzed of 128 patients with acute pancreatitis who were admitted in Fujian Provicial Hospital from Jan. 2001 to June 2003. Prothrombin time (PT), international normalized ratio (INR), partially activated thromboplastin time (APTT) and fibrinogen(FIB) were detected. Results With respect to PT, APTT, INR and FIB, there was significant difference between severe AP (SAP) and mild AP (MAP) groups(P < 0.01); there was significant difference between MODS and non MODS groups(P < 0.01); there was also significant difference between cured and died groups(P < 0.01); there was no statistical difference between biliary AP and non-biliary AP groups(P > 0.05);and there was no statistical difference between liver failure and non liver failure groups(P > 0.05). The was no significant correlation between PT, APTT, FIB and RANSON score in MAP group (P>0.05), while the correlation between PT, APTT, FIB and RANSON score in SAP and MODS groups was significant (P < 0.01). Conclusions Detection of coagulation function in AP patients is suggestive of prognosis of patients, and change of PT, APTT and FIB is not significantly related with cholepathia or liver dysfunction.更多还原