【摘要】 建立荷瘤小鼠模型,以不同剂量的SEP经腹腔注射给药后检测荷瘤小鼠的肿瘤生长情况、脾指数、胸腺指数、脾淋巴细胞增殖和抗氧化酶活性研究海胆黄多糖SEP的抗肿瘤活性。结果:SEP高、中、低3个剂量组均可显著抑制S180实体瘤的生长,其抑瘤率分别为46.9%、41.7%和40.7%;SEP能显著提高荷瘤小鼠的脾指数和胸腺指数,明显促进脾淋巴细胞的增殖,显著降低小鼠血清中丙二醛含量和提高超氧化物歧化酶活性。结论:SEP具有明显的抗肿瘤活性,其作用可能是通过免疫调节和抗氧化作用实现的。更多还原

【Abstract】 Effects of polysaccharide from the eggs of Strongylocentrotus nudus(SEP) on tumor in mice were investigated.The effects of SEP on Sarcoma 180(S180) tumor growth were observed after different doses of SEP were administered intraperitoneally(ip) to S180-bearing mice.The spleen index and thymus index,spleen lymphocyte proliferation,serum MDA content and SOD activity were also detected.Results showed that the growth of S180 tumor was significantly inhibited by SEP,the growth inhibitory rate of high,medium and low dosage was 46.9%、41.7% and 40.7% respectively.The spleen index and thymus index were enhanced significantly.The spleen lymphocyte proliferation was stimulated remarkably.The content of serum MDA was decreased notably and the activity of serum SOD was increased significantly.SEP could inhibit the growth of S180 tumor.The antitumor effect may be related to immunomodulation and anti-oxidative activity.更多还原