【摘要】 目的探讨在非小细胞肺癌中脆性组氨酸三联体(FHIT)基因及人类表皮生长因子受体2(HER2)表达与临床病理的关系,以及二者在非小细胞肺癌中的相关性。方法用免疫组化法检测50例肺癌组织及21例癌旁非肺癌组织的FHIT基因及HER2阳性表达率。结果肺癌组织中FHIT蛋白表达阳性率为30.00%,显著低于非肺癌组织的80.95%(P<0.05),而且FHIT基因的表达与组织类型、淋巴结转移、TNM临床分期有关。肺癌中存在HER2的过度表达,表达率为56.00%,并与淋巴结转移、TNM分期相关。FHIT基因的表达与HER2存在负相关关系,相关系数(r)=-0.38。结论在肺癌的发生、浸润、转移病变阶段中存在FHIT的表达下调和HER2的过度表达,二者呈负相关。更多还原

【Abstract】 Objective To examine the expressions of FHIT gene and HER₂ in non-small cell lung cancer（NSCLC）and the relationship between the expressions and the clinicopathological features of NSCLC, and to investigate the relationship between FHIT protein and HER₂ expression. Methods FHIT protein and HER₂ expressions in 50 lung cancer cases and 21 adjacent non-cancer tissues were performed by immunohistochemistry. And the positive rates of FHIT and HER₂ were measured. Results The positive rates of FHIT protein were 30.00% in lung cancer tissues. The expression levels of FHIT were significantly lower in lung cancer tissues than that in non-cancer lung tissues （P<0.005） compared with 80.95% in non-cancer lung tissues. The relationships between the expression and histological types, metastatichilar lymphnodes,TNM clinical stage. HER₂ were over-expressed in lung cancer in 56.00%. The over-expression of HER₂ correlates with the lymph node metastasis, TNM staging. An inverse correlation was found between FHIT protein expression and over-express HER₂ （r=-0.38,P<0.05）. Conclusions These data indicate that reduction of FHIT gene expression and over-expressed HER₂ are frequent in lung cancer. An inverse correlation was found between FHIT protein expression and over-expressed HER₂. They may be play an important role in the progression and metastasis of lung carcinoma.更多还原