【摘要】 目的:探讨甘草对慢性小鼠哮喘模型气道炎症及外周血Th1/Th2失衡的影响。方法:用卵蛋白致敏建立慢性小鼠哮喘模型,观察甘草对肺组织形态学影响,用ELISA法检测外周血肿瘤坏死因子-γ(IFN-γ)和白介素-4(IL-4)的水平变化。结果:与哮喘组小鼠相比较,甘草治疗后小鼠肺组织的炎症病理变化减轻,血清IFN-γ水平升高,IL-4水平降低。结论:甘草能有效抑制慢性哮喘产生的气道炎症,具有调节免疫平衡作用。更多还原

【Abstract】 AIM: To explore the effect of liquorice on airway inflammation and Th₁/Th₂ imbalance in chronic asthma. METHODS: The chronic asthma model was established by intraperitoneal ovalbumin. The effect of liquorice on mice model of chronic bronchial asthma was observed, and the levels of serum IFN-γ and IL-4 were tested by ELISA. RESULTS: Decreasing inflammatary cells infiltration in pulmonary tissue slices of tiny bronchial wall together with increasing serum IFN-γ and decreasing serum IL-4 levels. CONCLUSION: Liquorice can adjust Th₁/Th₂ imbalance and inhibit the airway inflammation.更多还原