【摘要】 目的:研究绵萆薢(Dioscoreaspongiosa)的化学成分。方法:利用大孔吸附树脂、硅胶柱层析、制备薄层色谱法进行分离纯化,根据化合物的理化性质和光谱数据鉴定结构。结果:从绵萆薢中分离得到5个化合物,分别鉴定为(3R,5S,7S)-1,7-二苯基-3,7-环氧-5-羟基-1-庚酮(命名为绵萆薢素A,化合物1)、(3S,5S,7S)-1,7-二苯基-3,7-环氧-5-羟基-1-庚酮(命名为绵萆薢素B,化合物2)、(+)-丁香树脂醇(化合物3)、胡椒醇(化合物4)、芝麻素酮(化合物5)。结论:化合物1、2为新化合物,化合物3、4和5是3个首次从薯蓣属分得的木脂素类化合物。更多还原

【Abstract】 Objective: To study the chemical constituents of Dioscorea spongiosa. Methods: The compounds wereisolated and purified by macroporous adsorption resin, silica gel column chromatography and preparative TLC chro-matography and their structures were identified on the basis of their physicochemical and spectral data. Results: Fivecompounds were obtained from the CHCl3-MeOH (V:V=10:3) fraction of 90% ethanol extract. Their structures wereelucidated as (3R, 5S, 7S)-1,7-diphenyl-3,7-epoxy-5-hydroxy-1-heptanone (Diospongin A,1), (3S, 5S, 7S) -1,7-diphenyl-3,7-epoxy-5-hydroxy-1-heptanone (Diospongin B,2), (+)-syringaresinol(3), piperitol(4), sesaminone(5).Conclusion: Compounds 1 and 2 are two new diarylheptanoids. Compounds 3, 4 and 5 were obtained from Dioscoreaas three lignans for the first time.更多还原