【摘要】 目的研究美托洛尔在老年性慢性心力衰竭治疗中的剂量及耐受性。方法对NYHA分级心功能Ⅱ~Ⅳ级129例老年患者在常规心衰治疗基础上加用美托洛尔,从极小剂量开始,逐渐增加剂量,目标分别为:①心率下降到55~60次/min(不低于50次/min);②稍加剂量心功能下降1级以上;③收缩压不低于12.00kPa。结果美托洛尔维持量为(80.7±34.1)mg/d。其中85例(65.89%)达心率目标,44例(34.11%)达心衰目标,血压无显著变化。结论在治疗期间内,心力衰竭(NYHAⅡ级~Ⅳ级)患者对美托洛尔耐受性较好。更多还原

【Abstract】 Objective To identify the target dose and tolerance of Metoprolol in treatment of elderly patients with chronic heart failure(CHF).Methods 129 patients with CHF of NYHA Ⅱ～Ⅳ were given conventional treatment plus Metoprolol,from minimal dose to large dose gradually.The target treatment was: ① the heart rate decreased to 55～60 beat/min(more than 50 beat/min);② the cardiac function decreased more than 1 degree after a little additional dose;③ the systolic blood pressure was less than 12.00 kPa.Results The maintenance dose of Metoprolol was(80.7±34.1)mg/d.Of 85 cases(65.89%) reached objective heart rate, of 44 cases(34.11%) reached objective heart failure and the blood pressure remained the same level.Conclusion A good tolerance and safety were found in patients with heart failure(NYHA Ⅱ～Ⅳ) during treatment.更多还原