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苯基(三甲基硅基亚甲基)锡二芳香酸酯的合成、结构和抗癌活性
Synthesis,Structure and Antitumour Activity of Phenyl-(trimethylsilylmethyl)tin Arylcarboxylates
【摘要】 采用苯基(三甲基硅基亚甲基)二溴化锡和芳香酸在三乙胺存在下,以1︰2的物质的量比进行反应,合成了10个新的含硅混合二烃基锡化合物苯基(三甲基硅基亚甲基)锡二芳香酸酯.利用IR,1HNMR,13CNMR和元素分析对它们的组成和结构进行了表征;部分化合物的生物活性测定结果表明,它们对某些癌细胞有较好的体外抗癌活性.
【Abstract】 Ten phenyl-(trimethylsilylmethyl)tin arylcarboxylates have been synthesized by the reaction of phenyl-(trimethylsilylmethyl)tin dibromide with arylcarboxylic acids.Their structures were characterized by elemental analysis,IR,1H NMR and 13C NMR spectra.The preliminary bioassay tests showed that they had a good antitumour activity in vitro against Hela and SPC-A-1 tumour cells.
【关键词】 混合二烃基锡化合物;
合成;
结构;
抗癌活性;
【Key words】 mixed diorganotin compound; synthesis; structure; antitumour activity;
【Key words】 mixed diorganotin compound; synthesis; structure; antitumour activity;
【基金】 江西省自然科学基金(No.0520064)资助项目.
- 【文献出处】 有机化学 ,Chinese Journal of Organic Chemistry , 编辑部邮箱 ,2006年06期
- 【分类号】R914;R73-3
- 【被引频次】29
- 【下载频次】136