节点文献
新型3-芳甲基-5-芳氧甲基丁内酯的合成及其抑制肺癌细胞生长活性评价
Synthesis and Primary Evaluation of Lung Cancer Cell Growth Inhi-bitory Activity of Novel 3-Arylmethyl-5-aroxymethylbutyrolactones
【摘要】 通过2-芳氧甲基环氧烷与α-芳甲基丙二酸二乙酯在乙醇钠条件下反应,合成了8个新型3-芳甲基-5-芳氧甲基丁内酯,收率为13%~81%.由IR,1HNMR和MS波谱数据进行了结构表征.所得化合物均具有抑制A549肺癌细胞生长的活性,其抑制效果具有浓度依赖性.
【Abstract】 A series of novel 3-arylmethyl-5-aroxymethylbutyrolactone derivatives were synthesized by the reaction of 2-aroxymethyloxirane derivatives with sodium diethyl α-arylmethylmalonates in yields of 13%~ 81%. These compounds were assayed for inhibitory activity against A549 lung cancer cell growth, and the inhibitory effects on the cell viability were dose-dependent.
【关键词】 2-芳氧甲基环氧烷;
α-芳甲基丙二酸二乙酯;
3-芳甲基-5-芳氧甲基丁内酯;
A549肺癌细胞;
生长抑制活性;
【Key words】 2-aroxymethyloxirane derivative; diethyl α-arylmethylmalonate derivative; 3-arylmethyl-5- aroxymethylbutyrolactone; A549 lung cancer cell; growth inhibitory activity;
【Key words】 2-aroxymethyloxirane derivative; diethyl α-arylmethylmalonate derivative; 3-arylmethyl-5- aroxymethylbutyrolactone; A549 lung cancer cell; growth inhibitory activity;
【基金】 教育部重点(No.104112);山东省自然科学基金(No.Z2002D05)资助项目
- 【文献出处】 有机化学 ,Chinese Journal of Organic Chemistry , 编辑部邮箱 ,2006年04期
- 【分类号】R914.5;R734.2
- 【被引频次】6
- 【下载频次】147