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麦斛细胞毒活性成分研究

Cytotoxic Constituents from Bulbuphyllum inconsipicum

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【作者】谭桂山；孙丽；曹建国；王秀梅；李福双；徐康平；邓银华；颜冬兰；章为；周应军；李元建；

【Author】 TAN, Gui-Shan*,a,b SUN, Lic CAO, Jian-Guoc WANG, Xiu-Meib LI, Fu-Shuangb XU, Kang-Pingb DENG, Yin-Huab YAN, Dong-Lanb ZHANG, Weib ZHOU, Ying-Junb LI, Yuan-Jianb (a Xiangya Hospital Affiliated to Central South University, Changsha 410008) (b School of Pharmaceutical Sciences, Central South University, Changsha 410013) (c Cancer Research Institute, Nanhua University, Hengyang 421001)

【机构】中南大学湘雅医院；南华大学肿瘤研究所；中南大学药学院；中南大学药学院长沙410008中南大学药学院长沙410013；衡阳421001；长沙410013；

【摘要】利用硅胶、聚酰胺柱层析等分离方法,从麦斛全草的乙醚萃取物中分离得到4个化合物,经化学方法和光谱分析(UV,IR,NMR,MS)鉴定为3,4,7-三羟基-2-甲氧基菲(1),2,5-二羟基-4-甲氧基菲(2),eugenitin(3)和2,5-二羟基-4-甲氧基-9,10-二氢菲(4),其中1为新化合物.采用MTT法分别测得化合物1和2对体外培养的人急性髓性白血病细胞和人肝癌细胞增殖的抑制活性,并分别考察了增敏剂葛根素对化合物1和2增殖活性的协同作用.更多还原

【Abstract】 A novel compound, 2-methoxy-3,4,7-trihydroxy-phenanthrene (1), along with 4-methoxy- 2,5-dihydroxy-phenathrene (2), eugenitin (3) and 2,5-dihydroxy-4-methoxy-9,10-dihydroxyphenanthrene (4), was isolated from Bulbuphyllum inconsipicum. 1 and 2 suppressing HL-60 and SMMC-7721 cells were investigated in vitro with cytotoxic activity. Furthermore, synergistic inhibition of 1 and 2 with puerarin was assessed.更多还原

【关键词】麦斛； 3,4,7-三羟基-2-甲氧基菲；人急性髓性白血病细胞；人肝癌细胞；葛根素；
【Key words】 Bulbuphyllum inconsipicum； 2-methoxy-3,4,7-trihydroxy-phenanthrene； cytotoxic activity； puerarin；

【文献出处】有机化学 ,Chinese Journal of Organic Chemistry , 编辑部邮箱 ,2006年03期

【分类号】R284
【被引频次】16
【下载频次】215

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