【摘要】 目的探讨3种细胞因子在结核、肺癌患者血清中浓度变化的意义。方法用ELISA法同步分别检测36例初治活动性结核、24例肺癌及12例健康对照组血清干扰素(IFN)-γ、白细胞介素(IL)-12、IL-4水平。结果结核组IFN-γ[包括痰集菌阳性、结核菌素试验(PPD)≤2+组)]明显高于肺癌组、健康对照组(P<0·05),肺癌组与对照组无区别;结核组IL-4高于肺癌组;60岁以下患者血清IFN-γ、IL-12浓度结核组高于肺癌组。结论细胞因子IFN-γ、IL-12、IL-4在结核与肺癌患者血清中浓度不同,可作为鉴别诊断的参考依据。更多还原

【Abstract】 Objective To study the significance of combined measurement of serum levels of IL-12, IFN-γ and IL-4 in the patients with pulmonary tuberculosis or lung cancer.Methods The levels of IL-12,IFN-γ and IL-4 were delected by ELISA in 36 patients with active pulmonary tuberculosis, 24 patients with lung cancer and 12 normal controls. Results The level of IFN-γ of patients with pulmonary tuberculosis (smear positive tuberculosis and PPD skin test ≤2+) was higher than that of the cases with lung cancer or normal controls(P<0.05).The level of IL-4 of tuberculosis group was higher than that of lung cancer group. In the patients under 60 years old, the levels of IFN-γ and IL-12 in patients with tuberculosis were also higher than those in patients with lung cancer. Conclusion The serum levels of IFN-γ,IL-12 and IL-4 are different between the patients with pulmonary tuberculosis and with lung cancer,and the detection of them can be used for differential diagnosis.更多还原