【摘要】 目的研究药物注射方式对二维实体肿瘤中药物输运的影响,确定较适当的注射方式。方法根据数值生成的肿瘤二维血管网,研究药物的输运。采用肿瘤中各部位药物浓度维持在最小药物浓度MEC水平以上的时间曲面下体积VUS来衡量药物的效果。对不同的施药注射方式进行了探讨。结果MEC较小时各种注射方式效果接近;MEC较大时,比较适合采用短时间集中注射方式。结论对肿瘤进行药物注射策略选取时,应根据肿瘤具体特性,以及药物施加方式对肿瘤细胞产生的不同作用来组合设计相应的优化施药方案。更多还原

【Abstract】 Objective The effect of injection strategy on drug transport in 2D solid tumor were investigated to determine the suitable injecting method. Methods By using the tumor capillary network based on numerical angiogenesis, drug transport in a two-dimensional solid tumor was studied. The volume under the surface (VUS) of drug concentration when higher than minimum effective concentration (MEC) in tumor during 24 hours was choosed to evaluate the treatment of drug. Various drug injection methods were investigated and compared. Results When MEC is relatively low, there is not significant difference for various drug injection methods. Injecting drug in a short period would be more effective if MEC is relatively high. Conclusion The drug injection strategies for solid tumor therapy should be designed and optimized according to the characters of tumor cells and the effect of various typical drug injection-methods.更多还原