【摘要】 目的:评价源自丈夫、工作场所以及生命早期家庭成员的环境烟草烟雾暴露与中国妇女全死因、恶性肿瘤或心血管疾病死亡率的关系。设计:中国上海正在进行的前瞻性队列研究。参加人员:72829名从不吸烟妇女中有65180人提供了其丈夫的吸烟资料,有66520人提供了源自工作场所和生命早期家庭成员的烟草烟雾暴露资料。主要的评价结果指标:全死因死亡率以及恶性肿瘤、心血管疾病死亡专率。按暴露状况分层的累积死亡率以及风险比。结果:源自丈夫的烟草烟雾暴露(主要是现时暴露)与全死因死亡率增加有显著联系,风险比(HR)为1．15,95％可信区间为1．01～1．31,与心血管疾病死亡率增加也有联系(1．37,1．06～1．78)。源自工作场所的烟草烟雾暴露与恶性肿瘤死亡率增加有联系(1．19,0．94～1．50),特别是肺癌(1．79,1．09～2．93)。生命早期暴露与心血管疾病死亡率增加有联系(1．26,0．94～1．69)。结论:在中国妇女中环境烟草烟雾暴露与全死因死亡率以及肺癌和心血管疾病死亡率的中等度增加有关。更多还原

【Abstract】 Objective To evaluate the association of environmental exposure to tobacco smoke from husbands and from work, as well as from family members in early life, with all cause mortality and mortality due to cancer or cardiovascular disease in Chinese women. Design Ongoing prospective cohort study in Shanghai, China. Participants Of 72 829 women who had never smoked, 65 180 women provided information on smoking by their husbands, and 66 520 women provided information on exposure to tobacco smoke at work and in early life from family members. Main outcome measures All cause mortality and cause specific mortality with the main focus on cancer and cardiovascular disease. Cumulative mortality according to exposure status, and hazard ratios. Results Exposure to tobacco smoke from husbands (mainly current exposure) was significantly associated with increased all cause mortality (hazard ratio 1.15, 95% confidence interval 1.01 to 1.31) and with increased mortality due to cardiovascular disease (1. 37,1.06 to 1. 78). Exposure to tobacco smoke at work was associated with increased mortality due to cancer (1. 19, 0. 94 to 1. 50) , especially lung cancer (1. 79, 1. 09 to 2. 93). Exposure in early life was associated with increased mortality due to cardiovascular disease (1.26,0.94 to 1.69). Conclusions In Chinese women, exposure to environmental tobacco smoke is related to moderately increased risk of all cause mortality and mortality due to lung cancer and cardiovascular disease.更多还原