【摘要】 目的:探讨早期2型糖尿病患者运动时骨骼肌氧代谢水平及外周血管功能变化。方法:采用近红外光谱(NIRS)测定技术,对34例早期2型糖尿病患者(糖尿病组)和9例正常人(对照组)足底屈运动时及运动结束后的腓肠肌氧合血红蛋白/肌红蛋白(OxyHb/Mb)的含量进行测定,并结合踝肱指数(ABPI)、四肢脉波速度(baPWV)等外周血管功能指标进行分析。结果:糖尿病组骨骼肌氧利用率(MO2)明显低于对照组(P<0.001),OxyHb/Mb的恢复时间(Tr)为15.9±9.6sec,与对照组10.2±4.5sec比较有延长趋势。糖尿病组ABPI为1.15±0.06,与对照组1.16±0.07比较无明显差异;糖尿病组baPWV为1520.2±211.8cm/sec,明显低于对照组1358.0±169.3cm/sec(P<0.05)。提示早期2型糖尿病患者骨骼肌氧利用降低。更多还原

【Abstract】 Purpose To analyze and explore the skeletal muscle oxygen supply and oxygen consumption, and the change in peripheral arterial function in patients with early type 2 diabetes mellitus during exercise.Methods Near infrared spectroscopy （NIRS） was adopted to observe the changes in content of oxygenated hemoglobin/mymoglobin（OxyHb/Mb） of gastrocnemius during and after ankle plantar flexion exercise in 34 patients with early type 2 diabetes mellitus and 9 age-matched healthy volunteer. OxyHb/Mb in combination with peripheral arterial function indexes, such as the ankle brachial pressure index （ABPI） and brachial ankle pulse wave velocity （baPWV） were analyzed and compared.Results Oxygen utilization rate of skeletal muscle （MO₂） in diabetic group is significantly lower than that in control group （P<0.001）, and the recovery time （Tr） of OxyHb/Mb in diabetic group is 15.9±9.6sec with somewhat longer than that in control group （ 10.2±4.5sec）. The ABPI of the diabetic group and control group are 1.15±0.06, and 1.16±0.07, respectively. The baPWV in diabetic group （1520.2±211.8cm/sec） is significantly lower than that in control group （1358.0±169.3cm/sec） （P<0.05）.Conclusion Oxygen consumption in skeletal muscle of patients with early type 2 diabetes mellitus during exercise are reduced.更多还原