【摘要】 质量性状中存在6种可能的基因互作类型,即互补、重叠、累加、显性上位、隐性上位和抑制。在遗传研究中,有时会遇到互作基因定位的问题,但至今未见有关互作基因定位方法和计算机软件的系统的研究报道。文章给出了基于极大似然估计的互作基因定位方法及相应的计算机软件(IGMapping1.0)。计算机模拟表明,此方法可以无偏地估计一个共显性标记与一个互作基因之间的重组率或连锁距离。更多还原

【Abstract】 There are six possible types of gene interaction in qualitative traits, namely, complementary, duplicate, cumulative, dominant epistasis, recessive epistasis and inhibiting. In genetic studies, the problem of mapping interactive genes may be met sometimes, but no systematic researches on the methodology and computer software for the mapping of interactive genes have been reported up to date. In this paper, methods for the mapping of interactive genes based on maximum-likelihood estimation and corresponding computer software (IGMapping 1.0) are presented. Computer simulations have shown that the methods proposed can unbiasedly estimate the recombination frequency or linkage distance between a codominant marker and an interactive gene.更多还原