【摘要】 精神分裂症是由多基因相互作用导致的复杂疾病。对其易感基因,儿茶酚氧位甲基转移酶基因(COMT)的众多报道充满了矛盾。在对偏执型精神分裂症研究中,我们用多基因座关联分析法研究了4个涉及神经递质多巴胺代谢的基因之间的相互作用。分析结果支持如下假说:COMT-136-BclⅠ对Val108/158Met有调控作用。当前者的基因型是CC时,后者的易感等位基因型是Met(A);而当前者的基因型是GG时,后者的易感等位基因型是Val(G)。这一新的假说可以解释此前单基因座分析对Val108/158Met(COMT)的截然相反的报道,同时也显示了多基因座分析对复杂疾病研究的必要性。更多还原

【Abstract】 Schizophrenia is a complex disease caused by interactions among multiple genes.Reports of one of its susceptibility genes,ethyltracatechol-O-mnsferase（COMT） have been conflicting.In the present study on paranoid schizophrenia,we have performed a multilocus association study to analyze the interactions among 4 genes that are involved in dopamine metabolism.Result supports the hypothesis that COMT-136-BclⅠ regulates Val^108/158Met.When the genotype of the former is CC,Met（A） is the genotype of susceptibility allele Val^108/158Met;and when the genotype of the former is GG,Val（G） is the genotype of susceptibility allele Val^108/158Met.This new hypothesis may explain the conflicting results about Val^108/158Met（COMT） obtained by single-locus analyses.It also illustrates that multilocus analysis is necessary for the research of complex diseases.更多还原