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基于支持向量机的拟南芥基因表达数据分析(英文)
Gene Expression Analysis with Support Vector Machines in Arabidopsis
【摘要】 针对拟南芥根部基因表达数据分析的问题,本文提出了一种新的基于距离度量学习的支持向机多分类算法.鉴于此问题的特殊性,本文通过最小化4分类机的LOO 误差来求得一个恰当的距离度量.并在此度量下找到若干个属于第5类(其它类)的训练点,从而构造出一个5分类机用来对所有基因分类.实验验证了此算法的可行性,并且比基因表达分析中传统使用的聚类方法更有效.
【Abstract】 For the problem of Arabidopsis root gene expression analysis, this paper presents a new algorithm of multi-class Support Vector Machines (SVMs) , which is based on learned distance measure. Because of speciality of this problem, a distance measure is learned by minimizing Leave-one-out (LOO) error of 4-class SVMs, and some genes belong to other classes are determined, then 5-class SVMs is constructed to classify the total genes. Experiments prove the effective of our method compared with traditional clustering methods.
【关键词】 运筹学;
支持向量机;
距离度量学习;
拟南芥;
基因表达谱;
【Key words】 Operation research; SVMs; learning distance metric; arabidopsis; gene Expression;
【Key words】 Operation research; SVMs; learning distance metric; arabidopsis; gene Expression;
【基金】 This work is supported by the National Natural Science Foundation of China(No.10371131).
- 【文献出处】 运筹学学报 ,Or Transactions , 编辑部邮箱 ,2006年02期
- 【分类号】O234
- 【被引频次】3
- 【下载频次】188